Cytosolic acetyl-CoA synthetase affected tumor cell  survival under hypoxia: the possible function in  tumor acetyl-CoA/acetate metabolism.

Y, Yoshii; T, Furukawa; H, Yoshii; T, Mori; Y, Kiyono; A, Waki; M, Kobayashi; T, Tsujikawa; T, Kudo; H, Okazawa; Y, Yonekura; Y, Fujibayashi

doi:10.1111/j.1349-7006.2009.01099.x

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Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism.

Shared by NobleBlocks on May 1, 2009 • 12:00 AM UTC

Authors:

Yoshii Y

Furukawa T

Yoshii H

Abstract

Understanding tumor-specific metabolism under hypoxia is important to find novel targets for antitumor drug design. Here we found that tumor cells expressed higher levels of cytosolic acetyl-CoA synthetase (ACSS2) under hypoxia than normoxia. Knockdown of ACSS2 by RNA interference (RNAi) in tumor ce...

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