Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism.

JP, Pujol; C, Chadjichristos; F, Legendre; C, Bauge; G, Beauchef; R, Andriamanalijaona; P, Galera; K, Boumediene

doi:10.1080/03008200802148355

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Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism.

Shared by NobleBlocks on Jan 1, 2008 • 12:00 AM UTC

Authors:

Pujol JP

Chadjichristos C

Legendre F

Abstract

In osteoarthritis (OA), interleukin-1 (IL-1) stimulates the expression of metalloproteinases and aggrecanases, which induce cartilage degradation. IL-1 is also capable of reducing the production of cartilage-specific macromolecules, including type II collagen, through modulation of the transcription...

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