Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.

Kisand, Kai; S Bøe Wolff, Anette; Trebusak Podkrajsek, Katarina; Tserel, Liina; Link, Maire; V Kisand, Kalle; Ersvaer, Elisabeth; Perheentupa, Jaakko; Moter Erichsen, Martina; Bratanic, Nina; Meloni, Antonella; Cetani, Filomena; Perniola, Roberto; Ergun-Longmire, Berrin; Maclaren, Noel; J E Krohn, Kai; Pura, Mikulás; Schalke, Berthold; Ströbel, Philipp; Isabel Leite, Maria; Battelino, Tadej; S Husebye, Eystein; Peterson, Pärt; Willcox, Nick; Meager, Anthony

doi:10.1084/jem.20091669

Public

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines.

Shared by NobleBlocks on Feb 15, 2010 • 12:00 AM UTC

Authors:

Kai Kisand

Anette S Bøe Wolff

Katarina Trebusak Podkrajsek

Abstract

Chronic mucocutaneous candidiasis (CMC) is frequently associated with T cell immunodeficiencies. Specifically, the proinflammatory IL-17A-producing Th17 subset is implicated in protection against fungi at epithelial surfaces. In autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED,...

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