Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody.

AM, Hernández; D, Toledo; D, Martínez; T, Griñán; V, Brito; A, Macías; S, Alfonso; T, Rondón; E, Suárez; AM, Vázquez; R, Pérez

doi:10.4049/jimmunol.181.9.6625

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Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody.

Shared by NobleBlocks on Nov 1, 2008 • 12:00 AM UTC

Authors:

Hernández AM

Toledo D

Martínez D

Abstract

1E10 mAb is an anti-Id murine mAb (Ab2 mAb) specific for an Ab1 mAb that reacts with NeuGc-containing gangliosides, sulfatides, and Ags expressed in some human tumors. In preclinical studies, this Ab2 Ab was able to mimic NeuGc-containing gangliosides only in animals lacking expression of these Ags ...

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