Metabolic engineering of morphinan alkaloids by over-expression and RNAi suppression of salutaridinol 7-O-acetyltransferase in opium poppy.

RS, Allen; JA, Miller; JA, Chitty; AJ, Fist; WL, Gerlach; PJ, Larkin

doi:10.1111/j.1467-7652.2007.00293.x

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Metabolic engineering of morphinan alkaloids by over-expression and RNAi suppression of salutaridinol 7-O-acetyltransferase in opium poppy.

Shared by NobleBlocks on Sep 13, 2007 • 12:00 AM UTC

Authors:

Allen RS

Miller JA

Chitty JA

Abstract

We demonstrate that both over-expression and suppression of the gene encoding the morphinan pathway enzyme salutaridinol 7-O-acetyltransferase (SalAT) in opium poppy affects the alkaloid products that accumulate. Over-expression of the gene in most of the transgenic events resulted in an increase in...

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