Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer.

HL, Kaufman; HJ, Lenz; J, Marshall; D, Singh; C, Garett; C, Cripps; M, Moore; Mehren M, von; R, Dalfen; WJ, Heim; RM, Conry; WJ, Urba; AB 3rd, Benson; M, Yu; J, Caterini; S, Kim-Schulze; M, Debenedette; D, Salha; T, Vogel; I, Elias; NL, Berinstein

doi:10.1158/1078-0432.ccr-08-0276

Public

Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer.

Shared by NobleBlocks on Aug 1, 2008 • 12:00 AM UTC

Authors:

Kaufman HL

Lenz HJ

Marshall J

Abstract

<h4>Purpose</h4>The combination of vaccines and chemotherapy holds promise for cancer therapy, but the effect of cytotoxic chemotherapy on vaccine-induced antitumor immunity is unknown. This study was conducted to assess the effects of systemic chemotherapy on ALVAC-CEA/B7.1-induced T-cell immunity ...

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