Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA<sub>A</sub>Receptor

Collinson, Neil; M. Kuenzi, Frederick; Jarolimek, Wolfgang; Maubach, Karen; Cothliff, Rosa; Sur, Cyrille; J. Smith, Alison; M. Otu, Franklin; W. Howell, Owain; Atack, John; M. McKernan, Ruth; R. Seabrook, Guy; R. Dawson, G.; J. Whiting, Paul; W. Rosahl, Thomas

doi:10.1523/jneurosci.22-13-05572.2002

Public

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

Published in Journal of Neuroscience • Jul 1, 2002

Authors:

Neil Collinson

Frederick M. Kuenzi

Wolfgang Jarolimek

Abstract

The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and the function of alpha5-containing GABA(A) receptors has been explored by targeted disruption of the alpha5 gene in mice. The alpha5 -/- ...

Subject

Hippocampal formation

Neuroscience

GABAergic

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