Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.

Liu, Suling; Cong, Yang; Wang, Dong; Sun, Yu; Deng, Lu; Liu, Yajing; Martin-Trevino, Rachel; Shang, Li; P McDermott, Sean; D Landis, Melissa; Hong, Suhyung; Adams, April; D'Angelo, Rosemarie; Ginestier, Christophe; Charafe-Jauffret, Emmanuelle; G Clouthier, Shawn; Birnbaum, Daniel; T Wong, Stephen; Zhan, Ming; C Chang, Jenny; S Wicha, Max

doi:10.1016/j.stemcr.2013.11.009

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Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.

Shared by NobleBlocks on Jan 14, 2014 • 12:00 AM UTC

Authors:

Suling Liu

Yang Cong

Dong Wang

Abstract

Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to relapse. Although several BCSC markers have been described, it is unclear whether these markers identify the same or independent BCSCs. Here, we sh...

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