Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.

Hirai, H; Tanaka, K; Yoshie, O; Ogawa, K; Kenmotsu, K; Takamori, Y; Ichimasa, M; Sugamura, K; Nakamura, M; Takano, S; Nagata, K

doi:10.1084/jem.193.2.255

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.

Shared by NobleBlocks on Jan 15, 2001 • 12:00 AM UTC

Authors:

H Hirai

K Tanaka

O Yoshie

Abstract

Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions...

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