Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice.

Degirolamo, Chiara; Rainaldi, Stefania; Bovenga, Fabiola; Murzilli, Stefania; Moschetta, Antonio

doi:10.1016/j.celrep.2014.02.032

Public

Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice.

Shared by NobleBlocks on Apr 10, 2014 • 12:00 AM UTC

Authors:

Chiara Degirolamo

Stefania Rainaldi

Fabiola Bovenga

Abstract

Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation. Microbial imprinting on BA signature modifies pool size and hydrophobicity, thus contributing to BA enterohepatic circulation. Microbiota-targeted thera...

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