Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).

R, Agnihotri; HC, Crawford; H, Haro; LM, Matrisian; MC, Havrda; L, Liaw

doi:10.1074/jbc.m103608200

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Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin).

Shared by NobleBlocks on May 25, 2001 • 12:00 AM UTC

Authors:

Agnihotri R

Crawford HC

Haro H

Abstract

Osteopontin (OPN) is a secreted phosphoprotein shown to function in wound healing, inflammation, and tumor progression. Expression of OPN is often co-localized with members of the matrix metalloproteinase (MMP) family. We report that OPN is a novel substrate for two MMPs, MMP-3 (stromelysin-1) and M...

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