Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.

MD, Tortorella; TC, Burn; MA, Pratta; I, Abbaszade; JM, Hollis; R, Liu; SA, Rosenfeld; RA, Copeland; CP, Decicco; R, Wynn; A, Rockwell; F, Yang; JL, Duke; K, Solomon; H, George; R, Bruckner; H, Nagase; Y, Itoh; DM, Ellis; H, Ross; BH, Wiswall; K, Murphy; MC Jr, Hillman; GF, Hollis; RC, Newton; RL, Magolda; JM, Trzaskos; EC, Arner

doi:10.1126/science.284.5420.1664

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.

Shared by NobleBlocks on Jun 1, 1999 • 12:00 AM UTC

Authors:

Tortorella MD

Burn TC

Pratta MA

Abstract

We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that clea...

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