Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group.

D, Davidson; ES, Barefield; J, Kattwinkel; G, Dudell; M, Damask; R, Straube; J, Rhines; CT, Chang

doi:10.1542/peds.101.3.325

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Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group.

Published in Pediatrics • Mar 1, 1998

Authors:

Davidson D

Barefield ES

Kattwinkel J

Abstract

<h4>Objectives</h4>To assess the dose-related effects of inhaled nitric oxide (I-NO) as a specific adjunct to early conventional therapy for term infants with persistent pulmonary hypertension (PPHN), with regard to neonatal outcome, oxygenation, and safety.<h4>Methods</h4>Randomized, placebo-contro...

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