<i>PIK3CA</i>
                    Mutations and Copy Number Gains in Human Lung Cancers

Yamamoto, Hiromasa; Shigematsu, Hisayuki; Nomura, Masaharu; W. Lockwood, William; Sato, Mitsuo; Okumura, Naoki; Soh, Junichi; Suzuki, Makoto; I. Wistuba, Ignacio; M. Fong, Kwun; Lee, Huei; Toyooka, Shinichi; Date, Hiroshi; L. Lam, Wan; D. Minna, John; F. Gazdar, Adi

doi:10.1158/0008-5472.can-07-5084

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<i>PIK3CA</i> Mutations and Copy Number Gains in Human Lung Cancers

Shared by NobleBlocks on Aug 28, 2008 • 12:00 AM UTC

Authors:

Hiromasa Yamamoto

Hisayuki Shigematsu

Masaharu Nomura

Abstract

Abstract We investigated the frequency and function of mutations and increased copy number of the PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes present in human cancers. We analyzed the mutational status of exons 9 and 20 and gene copy number of PIK3CA using 8...

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