Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

Francis, P.; Regan, M.; Fleming, G.; Láng, I.; Ciruelos, E.; Bellet, M.; Bonnefoi, H.; Climent, M.; D. Da Prada, G.; Burstein, H.; Martino, S.; Davidson, N.; Geyer, C.; Walley, B.; Coleman, R.; Kerbrat, P.; Buchholz, S.; Ingle, J.; Winer, E.; Rabaglio-Poretti, M.; Maibach, R.; Ruepp, B.; Giobbie-Hurder, A.; Price, K.; Colleoni, M.; Viale, G.; Coates, A.; Goldhirsch, A.; Gelber, R.

doi:10.1056/NEJMoa1412379

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Adjuvant Ovarian Suppression in Premenopausal Breast Cancer

Shared by NobleBlocks on Dec 11, 2014 • 12:00 AM UTC

Authors:

P. Francis

M. Regan

G. Fleming

Abstract

BACKGROUND Suppression of ovarian estrogen production reduces the recurrence of hormone-receptor– positive early breast cancer in premenopausal women, but its value when added to tamoxifen is uncertain. METHODS We randomly assigned 3066 premenopausal women, stratified according to prior receipt or n...

Subject

Medicine

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