Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

Melikian, George; Rhee, Soo‐Yon; Varghese, Vici; Porter, Danielle; White, Kirsten; Taylor, Jonathan; Towner, William; Troia, Paolo; H. Burack, Jeffrey; DeJesus, Edwin; K. Robbins, Gregory; Razzeca, Kristin; M. Kagan, Ron; F. Liu, Tommy; Jeffrey Fessel, W.; Israelski, Dennis; W. Shafer, Robert

doi:10.1093/jac/dkt316

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Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

Published in Journal of Antimicrobial Chemotherapy • Aug 9, 2013

Authors:

George Melikian

Soo‐Yon Rhee

Vici Varghese

Abstract

OBJECTIVES: The introduction of two new non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the past 5 years and the identification of novel NNRTI-associated mutations have made it necessary to reassess the extent of phenotypic NNRTI cross-resistance. METHODS: We analysed a dataset containin...

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Open Access

Subject

Rilpivirine

Etravirine

Efavirenz

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