Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

Shingai, Masashi; K. Donau, Olivia; J. Plishka, Ronald; Buckler‐White, Alicia; R. Mascola, John; J. Nabel, Gary; Nason, Martha; C. Montefiori, David; Moldt, Brian; Poignard, Pascal; Diskin, Ron; J. Björkman, Pamela; Eckhaus, Michael; Klein, Florian; Mouquet, Hugo; C. C. Lorenzi, Julio; Gazumyan, Anna; R. Burton, Dennis; C. Nussenzweig, Michel; A. Martin, Malcolm; Nishimura, Yoshiaki

doi:10.1084/jem.20132494

Public

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

Shared by NobleBlocks on Aug 25, 2014 • 12:00 AM UTC

Authors:

Masashi Shingai

Olivia K. Donau

Ronald J. Plishka

Abstract

It is widely appreciated that effective human vaccines directed against viral pathogens elicit neutralizing antibodies (NAbs). The passive transfer of anti-HIV-1 NAbs conferring sterilizing immunity to macaques has been used to determine the plasma neutralization titers, which must be present at the...

Subject

Virology

Monoclonal antibody

Antibody

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