Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.

Capone, Carmen; Cognat, Emmanuel; Ghezali, Lamia; Baron-Menguy, Céline; Aubin, Déborah; Mesnard, Laurent; Stöhr, Heidi; Domenga-Denier, Valérie; T Nelson, Mark; Joutel, Anne

doi:10.1002/ana.24573

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Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.

Shared by NobleBlocks on Mar 1, 2016 • 12:00 AM UTC

Authors:

Carmen Capone

Emmanuel Cognat

Lamia Ghezali

Abstract

OBJECTIVE: CADASIL is a genetic paradigm of cerebral small vessel disease caused by NOTCH3 mutations that stereotypically lead to the extracellular deposition of NOTCH3 ectodomain (Notch3(ECD) ) on the vessels. TIMP3 and vitronectin are 2 extracellular matrix proteins that abnormally accumulate in N...

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