Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.

Ratziu, V.; Harrison, S.; Francque, S.; Bedossa, P.; Lehert, P.; Serfaty, L.; Romero‐Gomez, M.; Boursier, J.; Abdelmalek, M.; Caldwell, S.; Drenth, J.; Anstee, Q.; Hum, D.; Hanf, Rémy; Roudot, A.; Megnien, S.; Staels, B.; Sanyal, A.

doi:10.1053/j.gastro.2016.01.038

Public

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.

Shared by NobleBlocks on May 1, 2016 • 12:00 AM UTC

Authors:

V. Ratziu

S. Harrison

S. Francque

Abstract

BACKGROUND & AIMS Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. We assessed the safety and efficacy of elafi...

Subject

Medicine

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