Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.

C, Bachert; L, Mannent; RM, Naclerio; J, Mullol; BJ, Ferguson; P, Gevaert; P, Hellings; L, Jiao; L, Wang; RR, Evans; G, Pirozzi; NM, Graham; B, Swanson; JD, Hamilton; A, Radin; NA, Gandhi; N, Stahl; GD, Yancopoulos; ER, Sutherland

doi:10.1001/jama.2015.19330

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Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.

Shared by NobleBlocks on Feb 1, 2016 • 12:00 AM UTC

Authors:

Bachert C

Mannent L

Naclerio RM

Abstract

<h4>Importance</h4>Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.<h4>Objective</h4>To assess inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal polyposis.<h4>Design...

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