Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

Ayton, Scott; G. Faux, Noel; I. Bush, Ashley; Disease Neuroimaging Initiative, Alzheimer's; W. Weiner, Michael; Aisen, Paul; Petersen, Ronald; R. Jack, Clifford; Jagust, William; Q. Trojanowki, John; W. Toga, Arthur; Beckett, Laurel; C. Green, Robert; J. Saykin, Andrew; Morris, John; M. Shaw, Leslie; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marc; Paul, Steven; Davies, Peter; Fillit, Howard; Hefti, Franz; Holtzman, Davie; Marcel Mesulam, M.; Potter, William; Snyder, Peter; Schwartz, Adam; Montine, Tom; G. Thomas, Ronald; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Jiminez, Gus; Harvey, Danielle; Bernstein, Matthew; Fox, Nick; Thompson, Paul; Schuff, Norbert; Borowski, Bret; Gunter, Jeff; Senjem, Matt; Vemuri, Prashanthi; Jones, David; Kantarci, Kejal; Ward, Chad; A. Koeppe, Robert; Foster, Norm; M. Reiman, Eric; Chen, Kewei; Mathis, Chet; Landau, Susan; J. Cairns, Nigel; Householder, Erin; Taylor-Reinwald, Lisa; Lee, Virginia; Korecka, Magdalena; Figurski, Michal; Crawford, Karen; Neu, Scott; M. Foroud, Tatiana; Potkin, Steven; Shen, Li; Faber, Kelley; Kim, Sungeun; Nho, Kwangsik; Thal, Leon; Buckholtz, Neil; Albert, Marylyn; Frank, Richard; Hsiao, John; Kaye, Jeffrey; Quinn, Joseph; Lind, Betty; Carter, Raina; Dolen, Sara; S. Schneider, Lon; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; M. Spann, Bryan; Brewer, James; Vanderswag, Helen; Fleisher, Adam; L. Heidebrink, Judith; L. Lord, Joanne; S. Mason, Sara; S. Albers, Colleen; Knopman, David; Johnson, Kris; S. Doody, Rachelle; Villanueva-Meyer, Javier; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; S. Honig, Lawrence; L. Bell, Karen; Ances, Beau; Carroll, Maria; Leon, Sue; A. Mintun, Mark; Schneider, Stacy; Oliver, Angela; Marson, Daniel; Griffith, Randall; Clark, David; Geldmacher, David; Brockington, John; Roberson, Erik; Grossman, Hillel; Mitsis, Effie; deToledo-Morrell, Leyla; C. Shah, Raj; Duara, Ranjan; Varon, Daniel; T. Greig, Maria; Roberts, Peggy; Albert, Marilyn; Onyike, Chiadi; D’Agostino II, Daniel; Kielb, Stephanie; E. Galvin, James; Cerbone, Brittany; A. Michel, Christina; Rusinek, Henry; J de Leon, Mony; Glodzik, Lidia; De Santi, Susan; Murali Doraiswamy, P.; R. Petrella, Jeffrey; Z. Wong, Terence; E. Arnold, Steven; H. Karlawish, Jason; Wolk, David; D. Smith, Charles; Jicha, Greg; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; L. Lopez, Oscar; Oakley, MaryAnn; M. Simpson, Donna; P. Porsteinsson, Anton; S. Goldstein, Bonnie; Martin, Kim; M. Makino, Kelly; Saleem Ismail, M.; Brand, Connie; A. Mulnard, Ruth; Thai, Gaby; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Diaz-Arrastia, Ramon; King, Richard; Weiner, Myron; Martin-Cook, Kristen; DeVous, Michael; I. Levey, Allan; J. Lah, James; S. Cellar, Janet; M. Burns, Jeffrey; S. Anderson, Heather; H. Swerdlow, Russell; Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; H.S. Silverman, Daniel; H. Lu, Po; Bartzokis, George; R Graff-Radford, Neill; Parfitt, Francine; Kendall, Tracy; Johnson, Heather; R. Farlow, Martin; Marie Hake, Ann; R. Matthews, Brandy; Herring, Scott; Hunt, Cynthia; H. van Dyck, Christopher; E. Carson, Richard; G. MacAvoy, Martha; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Robin Hsiung, Ging-Yuek; Feldman, Howard; Mudge, Benita; Assaly, Michele; Kertesz, Andrew; Rogers, John; Bernick, Charles

doi:10.1038/ncomms7760

Public

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

Shared by NobleBlocks on May 19, 2015 • 12:00 AM UTC

Authors:

Scott Ayton

Noel G. Faux

Ashley I. Bush

Abstract

Abstract Brain iron elevation is implicated in Alzheimer’s disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as ...

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