Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary.

H, Jang; OH, Lee; Y, Lee; H, Yoon; EM, Chang; M, Park; JW, Lee; K, Hong; JO, Kim; NK, Kim; JJ, Ko; DR, Lee; TK, Yoon; WS, Lee; Y, Choi

doi:10.1111/jpi.12316

Public

Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary.

Shared by NobleBlocks on Mar 2, 2016 • 12:00 AM UTC

Authors:

Jang H

Lee OH

Lee Y

Abstract

Premature ovarian failure (POF) is a major side effect of chemotherapy in young cancer patients. To develop pharmaceutical agents for preserving fertility, it is necessary to understand the mechanisms responsible for chemotherapy-induced follicle loss. Here, we show that treatment with cisplatin, a ...

Subject

Melatonin

Cisplatin

Premature ovarian failure

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