Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials.

JA, Roberts; MH, Abdul-Aziz; JS, Davis; JM, Dulhunty; MO, Cotta; J, Myburgh; R, Bellomo; J, Lipman

doi:10.1164/rccm.201601-0024oc

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Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials.

Shared by NobleBlocks on Sep 1, 2016 • 12:00 AM UTC

Authors:

Roberts JA

Abdul-Aziz MH

Davis JS

Abstract

<h4>Rationale</h4>Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention that may improve outcomes in severe sepsis.<h4>Objectives</h4>In this individual patient data meta-analysis of critically ill patients with severe sepsis, we aimed to compare clinical outcomes...

Subject

Pharmacokinetics

Antibiotic

Pharmacodynamics

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