Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.

YS, Chiou; ML, Tsai; K, Nagabhushanam; YJ, Wang; CH, Wu; CT, Ho; MH, Pan

doi:10.1021/jf2000103

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Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.

Shared by NobleBlocks on Feb 28, 2011 • 12:00 AM UTC

Authors:

Chiou YS

Tsai ML

Nagabhushanam K

Abstract

Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously, resveratrol (RS) and pterostilbene (P...

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