A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro.

F, Leonard; EM, Collnot; CM, Lehr

doi:10.1021/mp1000795

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A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro.

Published in Molecular pharmaceutics • Nov 1, 2010

Authors:

Leonard F

Collnot EM

Lehr CM

Abstract

While epithelial cell culture models (e.g., Caco-2 cell line) are widely used to assess the absorption of drug molecules across healthy intestinal mucosa, there are no suitable in vitro models of the intestinal barrier in the state of inflammation. Thus development of novel drugs and formulations fo...

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