Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.

X, Deng; A, Roessler; I, Brdar; R, Faessler; J, Wu; ZS, Sales; NS, Mani

doi:10.1021/jo201425q

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Direct, metal-free amination of heterocyclic amides/ureas with NH-heterocycles and N-substituted anilines in POCl3.

Shared by NobleBlocks on Sep 7, 2011 • 12:00 AM UTC

Authors:

Deng X

Roessler A

Brdar I

Abstract

A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic...

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