Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.

D, Gaudet; VJ, Alexander; BF, Baker; D, Brisson; K, Tremblay; W, Singleton; RS, Geary; SG, Hughes; NJ, Viney; MJ, Graham; RM, Crooke; JL, Witztum; JD, Brunzell; JJ, Kastelein

doi:10.1056/nejmoa1400283

Public

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.

Shared by NobleBlocks on Jul 1, 2015 • 12:00 AM UTC

Authors:

Gaudet D

Alexander VJ

Baker BF

Abstract

<h4>Background</h4>Apolipoprotein C-III (APOC3) is a key regulator of plasma triglyceride levels. Elevated triglyceride levels are associated with a risk of adverse cardiovascular events and pancreatitis. ISIS 304801 is a second-generation antisense inhibitor of APOC3 synthesis.<h4>Methods</h4>We co...

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