Multidrug-resistant tuberculosis and culture conversion with bedaquiline.

AH, Diacon; A, Pym; MP, Grobusch; los Rios JM, de; E, Gotuzzo; I, Vasilyeva; V, Leimane; K, Andries; N, Bakare; Marez T, De; M, Haxaire-Theeuwes; N, Lounis; P, Meyvisch; Paepe E, De; Heeswijk RP, van; B, Dannemann

doi:10.1056/nejmoa1313865

Public

Multidrug-resistant tuberculosis and culture conversion with bedaquiline.

Shared by NobleBlocks on Aug 1, 2014 • 12:00 AM UTC

Authors:

Diacon AH

Pym A

Grobusch MP

Abstract

<h4>Background</h4>Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen for 8 weeks.<h4>Methods</h4>In ...

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