Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.

I, Schweizer; K, Peters; C, Stahlmann; R, Hakenbeck; D, Denapaite

doi:10.1089/mdr.2014.0082

Public

Penicillin-binding protein 2x of Streptococcus pneumoniae: the mutation Ala707Asp within the C-terminal PASTA2 domain leads to destabilization.

Shared by NobleBlocks on May 19, 2014 • 12:00 AM UTC

Authors:

Schweizer I

Peters K

Stahlmann C

Abstract

Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) is an enzyme involved in the last stages of peptidoglycan assembly and essential for bacterial growth and survival. PBP2x localizes to the division site, a process that depends on its Penicillin-Binding Protein And Serine-Threonine-kinas...

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