A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.

EJ, Leslie; JC, Carlson; JR, Shaffer; E, Feingold; G, Wehby; CA, Laurie; D, Jain; CC, Laurie; KF, Doheny; T, McHenry; J, Resick; C, Sanchez; J, Jacobs; B, Emanuele; AR, Vieira; K, Neiswanger; AC, Lidral; LC, Valencia-Ramirez; AM, Lopez-Palacio; DR, Valencia; M, Arcos-Burgos; AE, Czeizel; LL, Field; CD, Padilla; la Paz EM, Cutiongco-de; F, Deleyiannis; K, Christensen; RG, Munger; RT, Lie; A, Wilcox; PA, Romitti; EE, Castilla; JC, Mereb; FA, Poletta; IM, Orioli; FM, Carvalho; JT, Hecht; SH, Blanton; CJ, Buxó; A, Butali; PA, Mossey; WL, Adeyemo; O, James; RO, Braimah; BS, Aregbesola; MA, Eshete; F, Abate; M, Koruyucu; F, Seymen; L, Ma; Salamanca JE, de; SM, Weinberg; L, Moreno; JC, Murray; ML, Marazita

doi:10.1093/hmg/ddw104

Public

A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13.

Shared by NobleBlocks on Mar 30, 2016 • 12:00 AM UTC

Authors:

Leslie EJ

Carlson JC

Shaffer JR

Abstract

Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 700 newborns. CL/P is phenotypically heterogeneous and has a complex etiology caused by genetic and environmental factor...

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