A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature

Mitchell, David; M. Coppert, David; Moynihan, H.A.; Lorenz, Kurt; Kissane, Marie; A. McNamara, Orla; R. Maguire, Anita

doi:10.1021/op200030t

Public

A Practical Synthesis of Biaryls via a Thermal Decarboxylative Pd-Catalyzed Cross-Coupling Reaction Operating at Moderate Temperature

Shared by NobleBlocks on Jul 18, 2011 • 12:00 AM UTC

Authors:

David Mitchell

David M. Coppert

H.A. Moynihan

Abstract

The palladium-catalyzed decarboxylative cross-coupling of aminothiophene carboxylate and 1-bromo-4-chlorobenzene to produce 3-amino-2-(4-chlorophenyl)thiophene (2) is described. The cross-coupling proceeds under relatively mild conditions using catalytic Pd(0) and TBAB. Through use of a mixed-solven...

Subject

Chlorobenzene

Catalysis

Chemistry

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