NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.

H, Satoh; T, Moriguchi; D, Saigusa; L, Baird; L, Yu; H, Rokutan; K, Igarashi; M, Ebina; T, Shibata; M, Yamamoto

doi:10.1158/0008-5472.can-15-1584

Public

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.

Shared by NobleBlocks on Mar 28, 2016 • 12:00 AM UTC

Authors:

Satoh H

Moriguchi T

Saigusa D

Abstract

Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations in Nrf2 also confer malignant characters to human cells by activating antioxidative/detoxifying enzymes and metabolic reprogramming. In this study, we examined how these contradictory activities...

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