Emergence of zidovudine and multidrug-resistance mutations in the HIV-1 reverse transcriptase gene in therapy-naive patients receiving stavudine plus didanosine combination therapy. STADI Group.

I, Pellegrin; J, Izopet; J, Reynes; M, Denayrolles; B, Montes; JL, Pellegrin; P, Massip; J, Puel; H, Fleury; M, Segondy

doi:10.1097/00002030-199909100-00014

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Emergence of zidovudine and multidrug-resistance mutations in the HIV-1 reverse transcriptase gene in therapy-naive patients receiving stavudine plus didanosine combination therapy. STADI Group.

Shared by NobleBlocks on Sep 1, 1999 • 12:00 AM UTC

Authors:

Pellegrin I

Izopet J

Reynes J

Abstract

<h4>Objective</h4>Assessment of genotypic changes in the reverse transcriptase gene of HIV-1 occurring in antiretroviral naive patients treated by stavudine plus didanosine combination therapy.<h4>Methods</h4>Sequence analysis (codons 1-230) was performed after amplification of the reverse transcrip...

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