Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice.

EM, Chang; E, Lim; S, Yoon; K, Jeong; S, Bae; DR, Lee; TK, Yoon; Y, Choi; WS, Lee

doi:10.1371/journal.pone.0144245

Public

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice.

Shared by NobleBlocks on Dec 14, 2015 • 12:00 AM UTC

Authors:

Chang EM

Lim E

Yoon S

Abstract

Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a...

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