Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.

EH, Giannini; EJ, Brewer; N, Kuzmina; A, Shaikov; A, Maximov; I, Vorontsov; CW, Fink; AJ, Newman; JT, Cassidy; LS, Zemel

doi:10.1056/nejm199204163261602

Public

Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.

Shared by NobleBlocks on Apr 1, 1992 • 12:00 AM UTC

Authors:

Giannini EH

Brewer EJ

Kuzmina N

Abstract

<h4>Background</h4>The antimetabolite methotrexate has been shown in placebo-controlled trials to be effective in adults with rheumatoid arthritis. Methotrexate may also be effective in children with resistant juvenile rheumatoid arthritis, but the supporting data are from uncontrolled trials.<h4>Me...

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