Identification of novel bile acids as biomarkers for the early diagnosis of Niemann-Pick C disease.

F, Mazzacuva; P, Mills; K, Mills; S, Camuzeaux; P, Gissen; ER, Nicoli; C, Wassif; Vruchte D, Te; FD, Porter; M, Maekawa; N, Mano; T, Iida; F, Platt; PT, Clayton

doi:10.1002/1873-3468.12196

Public

Identification of novel bile acids as biomarkers for the early diagnosis of Niemann-Pick C disease.

Shared by NobleBlocks on May 27, 2016 • 12:00 AM UTC

Authors:

Mazzacuva F

Mills P

Mills K

Abstract

This article describes a rapid UPLC-MS/MS method to quantitate novel bile acids in biological fluids and the evaluation of their diagnostic potential in Niemann-Pick C (NPC). Two new compounds, NPCBA1 (3β-hydroxy,7β-N-acetylglucosaminyl-5-cholenoic acid) and NPCBA2 (probably 3β,5α,6β-trihydroxychola...

Subject

Screening

Biomarkers

Bile acids

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