Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells.

A, Dimozi; E, Mavrogonatou; A, Sklirou; D, Kletsas

doi:10.22203/ecm.v030a07

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Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells.

Shared by NobleBlocks on Sep 4, 2015 • 12:00 AM UTC

Authors:

Dimozi A

Mavrogonatou E

Sklirou A

Abstract

Aged and degenerated intervertebral discs are characterised by a significant increase in the number of senescent cells, which may be associated with the deterioration of this tissue due to their catabolic phenotype. On the other hand, carboxymethyl-lysine has been found to be accumulated with ageing...

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