Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity.

E, Shikata; I, Ieiri; S, Ishiguro; H, Aono; K, Inoue; T, Koide; S, Ohgi; K, Otsubo

doi:10.1182/blood-2003-09-3043

Public

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivity.

Shared by NobleBlocks on Dec 4, 2003 • 12:00 AM UTC

Authors:

Shikata E

Ieiri I

Ishiguro S

Abstract

We analyzed mutations of 7 vitamin K-dependent protein and cytochrome P450 2C9 genes in 45 patients and investigated whether any contribute to the large interpatient variability in the warfarin dose-effect relationship. Total clearance and daily dose, INR and INR/Cp, were used as pharmacokinetic and...

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