Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

Y, Cormerais; S, Giuliano; R, LeFloch; B, Front; J, Durivault; E, Tambutté; PA, Massard; la Ballina LR, de; H, Endou; MF, Wempe; M, Palacin; SK, Parks; J, Pouyssegur

doi:10.1158/0008-5472.can-15-3376

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Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth.

Shared by NobleBlocks on Jun 14, 2016 • 12:00 AM UTC

Authors:

Cormerais Y

Giuliano S

LeFloch R

Abstract

The CD98/LAT1 complex is overexpressed in aggressive human cancers and is thereby described as a potential therapeutic target. This complex promotes tumorigenesis with CD98 (4F2hc) engaging β-integrin signaling while LAT1 (SLC7A5) imports essential amino acids (EAA) and promotes mTORC1 activity. How...

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