Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model.

Huang, Zhengrong; Chen, Xiao-Jun; Qian, Cheng; Dong, Qian; Ding, Dan; Wu, Qiong-Feng; Li, Jing; Wang, Hong-Fei; Li, Wei-Hua; Xie, Qiang; Cheng, Xiang; Zhao, Ning; Du, Yi-Mei; Liao, Yu-Hua

doi:10.1161/circep.115.003396

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Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model.

Shared by NobleBlocks on Jul 1, 2016 • 12:00 AM UTC

Authors:

Zhengrong Huang

Xiao-Jun Chen

Cheng Qian

Abstract

BACKGROUND: Postoperative atrial fibrillation is a frequent complication in cardiac surgery. The aberrant activation of signal transducer and activator of transcription 3 (STAT3) contributes to the pathogenesis of atrial fibrillation. MicroRNA-21 (miR-21) promotes atrial fibrosis. Recent studies sup...

Subject

arrhythmia

atrial fibrillation

microRNA

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