Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

Nishida, Keiji; Arazoe, Takayuki; Yachie, Nozomu; Banno, Satomi; Kakimoto, Mika; Tabata, Mayura; Mochizuki, Masao; Miyabe, Aya; Araki, Michihiro; Y. Hara, Kiyotaka; Shimatani, Zenpei; Kondo, Akihiko

doi:10.1126/science.aaf8729

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Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

Shared by NobleBlocks on Sep 16, 2016 • 12:00 AM UTC

Authors:

Keiji Nishida

Takayuki Arazoe

Nozomu Yachie

Abstract

INTRODUCTION To combat invading pathogens, cells develop an adaptive immune response by changing their own genetic information. In vertebrates, the generation of genetic variation (somatic hypermutation) is an essential process for diversification and affinity maturation of antibodies that function ...

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