Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.

ME, Rodriguez-Ruiz; I, Rodriguez; S, Garasa; B, Barbes; JL, Solorzano; JL, Perez-Gracia; S, Labiano; MF, Sanmamed; A, Azpilikueta; E, Bolaños; AR, Sanchez-Paulete; MA, Aznar; A, Rouzaut; KA, Schalper; M, Jure-Kunkel; I, Melero

doi:10.1158/0008-5472.can-16-0549

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Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming.

Shared by NobleBlocks on Aug 22, 2016 • 12:00 AM UTC

Authors:

Rodriguez-Ruiz ME

Rodriguez I

Garasa S

Abstract

Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor lesions and on distant, nonirradiated tumor sites. The combination of radiotherapy with immunostimulatory anti-PD1 and an...

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