Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

A. May, Scott; D. Johnson, Martin; Y. Buser, Jonas; N. Campbell, Alison; A. Frank, Scott; D. Haeberle, Brian; C. Hoffman, Philip; R. Lambertus, Gordon; D. McFarland, Adam; D. Moher, Eric; White, Timothy; Declan Hurley, D.; P. Corrigan, Aoife; Gowran, Olivia; G. Kerrigan, Niall; Kissane, Marie; R. Lynch, Regina; Sheehan, Paul; D. Spencer, Richard; R. Pulley, Shon; R. Stout, James

doi:10.1021/acs.oprd.6b00148

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Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction

Shared by NobleBlocks on Oct 19, 2016 • 12:00 AM UTC

Authors:

Scott A. May

Martin D. Johnson

Jonas Y. Buser

Abstract

The design, development, and scale up of a continuous iridium-catalyzed homogeneous high pressure reductive amination reaction to produce 6, the penultimate intermediate in Lilly's CETP inhibitor evacetrapib, is described. The scope of this report involves initial batch chemistry screening at millig...

Subject

Reductive amination

Amination

Process development

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