Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

Simone M, De; A, Arrigoni; G, Rossetti; P, Gruarin; V, Ranzani; C, Politano; RJP, Bonnal; E, Provasi; ML, Sarnicola; I, Panzeri; M, Moro; M, Crosti; S, Mazzara; V, Vaira; S, Bosari; A, Palleschi; L, Santambrogio; G, Bovo; N, Zucchini; M, Totis; L, Gianotti; G, Cesana; RA, Perego; N, Maroni; Ceretti A, Pisani; E, Opocher; Francesco R, De; J, Geginat; HG, Stunnenberg; S, Abrignani; M, Pagani

doi:10.1016/j.immuni.2016.10.021

Public

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

Shared by NobleBlocks on Nov 1, 2016 • 12:00 AM UTC

Authors:

De Simone M

Arrigoni A

Rossetti G

Abstract

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus offer therapeutic opportunities. Transcriptomes of T helper 1 (Th1), Th17, and Treg cells infiltrating colorectal or...

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