Transcription Factor EB Controls Metabolic Flexibility during Exercise.

G, Mansueto; A, Armani; C, Viscomi; L, D'Orsi; Cegli R, De; EV, Polishchuk; C, Lamperti; Meo I, Di; V, Romanello; S, Marchet; PK, Saha; H, Zong; B, Blaauw; F, Solagna; C, Tezze; P, Grumati; P, Bonaldo; JE, Pessin; M, Zeviani; M, Sandri; A, Ballabio

doi:10.1016/j.cmet.2016.11.003

Public

Transcription Factor EB Controls Metabolic Flexibility during Exercise.

Shared by NobleBlocks on Dec 20, 2016 • 12:00 AM UTC

Authors:

Mansueto G

Armani A

Viscomi C

Abstract

The transcription factor EB (TFEB) is an essential component of lysosomal biogenesis and autophagy for the adaptive response to food deprivation. To address the physiological function of TFEB in skeletal muscle, we have used muscle-specific gain- and loss-of-function approaches. Here, we show that T...

Subject

Mitochondria

Insulin

Glucose

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