Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity

K. Lensjø, K.; Lepperød, M.; Dick, Gunnar; Hafting, T.; Fyhn, M.

doi:10.1523/JNEUROSCI.2504-16.2016

Public

Removal of Perineuronal Nets Unlocks Juvenile Plasticity Through Network Mechanisms of Decreased Inhibition and Increased Gamma Activity.

Shared by NobleBlocks on Dec 30, 2016 • 12:00 AM UTC

Authors:

Lensjø KK

Lepperød ME

Dick G

Abstract

Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of the period of heightened visual cortex plasticity in juveniles, whereas removal of PNNs in adults reopens for plasticity. The mecha...

Subject

Inhibition

Local Field Potential

Cortical Plasticity

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