T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

CS, Kuo; S, Pavlidis; M, Loza; F, Baribaud; A, Rowe; I, Pandis; A, Sousa; J, Corfield; R, Djukanovic; R, Lutter; PJ, Sterk; C, Auffray; Y, Guo; IM, Adcock; KF, Chung

doi:10.1183/13993003.02135-2016

Public

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

Shared by NobleBlocks on Feb 8, 2017 • 12:00 AM UTC

Authors:

Kuo CS

Pavlidis S

Loza M

Abstract

Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes betwe...

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