Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Significance β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis. Using a panel of GPCRs believed to couple differently to βarrs, we demonstrate how distinct conformations of GPCR–... View More