A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.

P, Liu; M, Ge; J, Hu; X, Li; L, Che; K, Sun; L, Cheng; Y, Huang; MG, Pilo; A, Cigliano; GM, Pes; RM, Pascale; S, Brozzetti; G, Vidili; A, Porcu; A, Cossu; G, Palmieri; MC, Sini; S, Ribback; F, Dombrowski; J, Tao; DF, Calvisi; L, Chen; X, Chen

doi:10.1002/hep.29183

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A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.

Shared by NobleBlocks on May 22, 2017 • 12:00 AM UTC

Authors:

Liu P

Ge M

Hu J

Abstract

Amplification and/or activation of the c-Myc proto-oncogene is one of the leading genetic events along hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the finding that its overexpression in the mouse liver triggers tumor formation. However, the molecular mech...

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