Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

R. K. Ali, Moustafa; Aminur Rahman, Mohammad; Wu, Yue; Han, Tiegang; Peng, Xianghong; Mackey, Megan; Wang, Dongsheng; Ju C. Shin, Hyung; G. Chen, Zhuo; Xiao, Haopeng; Wu, Ronghu; Tang, Yan; M. Shin, Dong; A. El‐Sayed, Mostafa

doi:10.1073/pnas.1619302114

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Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

Published in Proceedings of the National Academy of Sciences • Mar 29, 2017

Authors:

Moustafa R. K. Ali

Mohammad Aminur Rahman

Yue Wu

Abstract

Significance This is a systematic in vivo study of gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) for cancer. We have optimized the properties of our AuNRs and the conditions of PPTT to achieve maximal induction of tumor apoptosis. To examine the molecular mechanisms of a...

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Open Access

Subject

Apoptosis

Photothermal therapy

Toxicity

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